RNA-binding proteins in neurodegeneration: mechanisms in aggregate.

prokaryotic and eukaryotic DNA-binding proteins in Escherichia coli

The second part is a pair of regulatable protein expression vectors that permit in vivo production of the target protein at levels appropriate for genetic experiments. When expressed in a properly designed reporter strain, the target protein represses the lac genes, resulting in an E.coli phenotype that can be quantitatively measured or exploited in large-scale …

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A pneumonia outbreak associated with a new coronavirus of probable bat origin

Here we report the identification and characterization of a novel coronavirus¬†(2019-nCoV) that caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, has caused 2,050 laboratory-confirmed infections with 56 fatal cases by 26 January 2020. Full-length genome sequences were obtained from five patients at the …

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RNA-binding proteins in neurodegeneration: mechanisms in aggregate.

RNA-binding proteins in neurodegeneration: mechanisms in aggregate.

Neurodegeneration is a number one reason for loss of life in the developed world and a pure, albeit unlucky, consequence of longer-lived populations. Despite nice demand for therapeutic intervention, it’s typically the case that these ailments are insufficiently understood on the fundamental molecular degree. What little is thought has prompted a lot hopeful hypothesis a …

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