EXPANDER–an integrative program suite for microarray data analysis

prokaryotic and eukaryotic DNA-binding proteins in Escherichia coli

The second part is a pair of regulatable protein expression vectors that permit in vivo production of the target protein at levels appropriate for genetic experiments. When expressed in a properly designed reporter strain, the target protein represses the lac genes, resulting in an E.coli phenotype that can be quantitatively measured or exploited in large-scale …

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A pneumonia outbreak associated with a new coronavirus of probable bat origin

Here we report the identification and characterization of a novel coronavirus¬†(2019-nCoV) that caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, has caused 2,050 laboratory-confirmed infections with 56 fatal cases by 26 January 2020. Full-length genome sequences were obtained from five patients at the …

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EXPANDER--an integrative program suite for microarray data analysis

EXPANDER–an integrative program suite for microarray data analysis

Gene expression microarrays are a prominent experimental tool in functional genomics which has opened the opportunity for gaining global, systems-level understanding of transcriptional networks. Experiments that apply this technology typically generate overwhelming volumes of data, unprecedented in biological research. Therefore the task of mining meaningful biological knowledge out of the raw data is a major challenge in …

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