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prokaryotic and eukaryotic DNA-binding proteins in Escherichia coli
The second part is a pair of regulatable protein expression vectors that permit in vivo production of the target protein at levels appropriate for genetic experiments. When expressed in a properly designed reporter strain, the target protein represses the lac genes, resulting in an E.coli phenotype that can be quantitatively measured or exploited in large-scale …
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
Here we report the identification and characterization of a novel coronavirus (2019-nCoV) that caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, has caused 2,050 laboratory-confirmed infections with 56 fatal cases by 26 January 2020. Full-length genome sequences were obtained from five patients at the …
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RNA-binding proteins in neurodegeneration: mechanisms in aggregate.
Neurodegeneration is a number one reason for loss of life in the developed world and a pure, albeit unlucky, consequence of longer-lived populations. Despite nice demand for therapeutic intervention, it’s typically the case that these ailments are insufficiently understood on the fundamental molecular degree. What little is thought has prompted a lot hopeful hypothesis a …
RNA-binding proteins in neurodegeneration: mechanisms in aggregate. Read More »
Improving the visibility of developmental biology: time for induction and specification.
Developmental biology is a distinguished discipline that has captured the creativeness of many scientists. Over the years, analysis in the space has seen a gentle quantity of superb accomplishments, with peaks in exercise following the growth and software of new applied sciences. Although the discipline continues to flourish and produce wonderful work, I’ve just lately observed problem …
Improving the visibility of developmental biology: time for induction and specification. Read More »
Were our critics right about the Stasi?
Disinformation, now greatest recognized generically as “faux information,” is an outdated and protean weapon. Prominent in the 1980s was AIDS disinformation, together with the HIV-from-Fort-Detrick fantasy, for whose propagation some figures in the end admitted blame whereas others shamelessly claimed credit score. In 2013 we reported a complete evaluation of this fantasy, discovering main roles for the …
Current Affairs of Microbial Genome-Wide Association Studies: Approaches, Bottlenecks and Analytical Pitfalls
The transduction of indicators within the PTEN/PI3-kinase (PI3K) pathway is constructed round a phosphoinositide (PIP) lipid messenger, phosphatidylinositol trisphosphate, PI(3,4,5)P3 or PIP3 Another, extra historical function of this household of messengers is the management of endocytosis, the place a handful of separate PIPs act like postal codes. Prominent amongst them is PI(3)P, which helps to make sure that endocytic …
Current Affairs of Microbial Genome-Wide Association Studies: Approaches, Bottlenecks and Analytical Pitfalls
Microbial genome-wide affiliation research (mGWAS) are a brand new and thrilling analysis discipline that’s adapting human GWAS strategies to grasp how variations in microbial genomes have an effect on host or pathogen phenotypes, resembling drug resistance, virulence, host specificity and prognosis. Several computational instruments and strategies have been developed or tailored from human GWAS to …
EXPANDER–an integrative program suite for microarray data analysis
Gene expression microarrays are a prominent experimental tool in functional genomics which has opened the opportunity for gaining global, systems-level understanding of transcriptional networks. Experiments that apply this technology typically generate overwhelming volumes of data, unprecedented in biological research. Therefore the task of mining meaningful biological knowledge out of the raw data is a major challenge in …
EXPANDER–an integrative program suite for microarray data analysis Read More »